Matthieu JABAUDON
M.D., Ph.D.
Resume
Professor of Anesthesiology, Critical Care, and Perioperative Medicine
Department of Anesthesiology, Critical Care, and Perioperative Medicine, CHU Clermont-Ferrand
Team « Translational Approach to epithelial injury and repair”, iGReD, Universite Clermont Auvergne, CNRS, INSERM
58 rue Montalembert, 63000 Clermont-Ferrand, France
Email: mjabaudon@chu.clermontferrand.fr
Education
MD in Anesthesiology, Critical Care, and Perioperative Medicine - CHU Clermont-Ferrand, Université Clermont Auvergne (2008)
PhD in Biological Sciences - Université Clermont Auvergne, GReD, CNRS, INSERM (2016)
Postgraduate Training
Visiting Associate Professor of Medicine, Vanderbilt University Medical Center (2019-2020)
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Research
Research Keywords
Translational research in acute lung injury and repair; Acute respiratory distress syndrome; Mechanical ventilation; Inhaled anesthetics; Biomarkers; Personalized Medicine.
Research Description
Our Hospital research team and University lab do basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome (ARDS). Current projects include studies of the effects of inhaled anesthetics (sevoflurane, isoflurane) in acute lung injury and repair, investigation of the role of the receptor for advanced glycation end-products (RAGE) pathway and of the alveolar epithelium in the pathogenesis and resolution of acute lung injury, and translational studies of biomarkers for diagnosis and prognosis in acute lung injury
Publications
ORCID
Publications
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2024
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“Balancing patient needs with environmental impacts for best practices in general anesthesia: Narrative review and clinical perspective.”, Anaesthesia, critical care & pain medicine, vol. 43 (4) , pp. 101389, 2024.
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“Volatile Anesthetic Sedation for Critically Ill Patients.”, Anesthesiology, vol. 141 (1) , pp. 163–174, 2024.
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“Effects of sevoflurane on lung alveolar epithelial wound healing and survival in a sterile in vitro model of acute respiratory distress syndrome.”, Exp. Cell Res., vol. 438 (1) , pp. 114030, 2024.
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“Beyond the Surviving Sepsis Campaign Guidelines: a systematic review of interventions affecting mortality in sepsis.”, Panminerva medica, vol. 66 (1) , pp. 55–62, 2024.
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“Sedation with volatile anaesthetics in intensive care.”, BJA education, vol. 24 (3) , pp. 77–80, 2024.
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“Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep.”, International journal of molecular sciences, vol. 25 (4) , 2024.
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2021
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“Importance of Lung Epithelial Injury in COVID-19-associated Acute Respiratory Distress Syndrome: Value of Plasma Soluble Receptor for Advanced Glycation End-Products.”, American journal of respiratory and critical care medicine, vol. 204 (3) , pp. 359–362, 2021.
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“Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome.”, Journal of clinical medicine, vol. 10 (10) , 2021.
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“The 'ephemeral' intensive care units that saved the French healthcare system, a new concept to be preserved.”, European journal of anaesthesiology, vol. 38 (4) , pp. 441–442, 2021.
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“Biomarkers in acute respiratory distress syndrome.”, Current opinion in critical care, vol. 27 (1) , pp. 46–54, 2021.
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“Use of volatile agents for sedation in the intensive care unit: A national survey in France.”, PLoS ONE, vol. 16 (4) , pp. e0249889, 2021.
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2020
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“Analgesia and sedation in patients with ARDS.”, Intensive care medicine, 2020.
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“Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device.”, Journal of visualized experiments : JoVE, 2020.
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“Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.”, Chest, 2020.
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“The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study.”, Exp. Cell Res., vol. 391 (2) , pp. 112030, 2020.
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“Eyes wide open on bronchial aeration in acute respiratory distress syndrome.”, Anaesthesia, critical care & pain medicine, vol. 39 (2) , pp. 191–192, 2020.
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“Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.”, Respiratory research, vol. 21 (1) , pp. 81, 2020.
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“Advanced Glycation End Products and Receptor (RAGE) Promote Wound Healing of Human Corneal Epithelial Cells.”, Investigative ophthalmology & visual science, vol. 61 (3) , pp. 14, 2020.
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2019
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“Encou-RAGE-ing Lung Protection in Patients With Acute Respiratory Distress Syndrome Under Extracorporeal Membrane Oxygenation.”, Critical care medicine, vol. 47 (11) , pp. 1654–1655, 2019.
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“ARDS in patients with chest trauma: Better safe than sorry.”, Anaesthesia, critical care & pain medicine, vol. 38 (3) , pp. 221–222, 2019.
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“Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets.”, Scientific reports, vol. 9 (1) , pp. 9227, 2019.
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“Pathological Implications of Receptor for Advanced Glycation End-Product (AGER) Gene Polymorphism.”, Disease markers, vol. 2019 , pp. 2067353, 2019.
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2018
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“Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.”, Pediatric pulmonology, vol. 53 (10) , pp. 1429–1435, 2018.
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“In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells.”, Journal of visualized experiments : JoVE, 2018.
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“Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.”, Intensive care medicine, vol. 44 (9) , pp. 1388–1399, 2018.
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“Driving pressure and acute respiratory distress syndrome in critically ill patients.”, Respirology (Carlton, Vic.), 2018.
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“Understanding Macrophages in Acute Respiratory Distress Syndrome: From Pathophysiology to Precision Medicine.”, Critical care medicine, vol. 46 (7) , pp. 1207–1208, 2018.
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“Recent directions in personalised acute respiratory distress syndrome medicine.”, Anaesthesia, critical care & pain medicine, vol. 37 (3) , pp. 251–258, 2018.
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“Distinct Biological Effects of Time-Controlled Adaptive Ventilation in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome: "One Small Step for Rats, One Giant Leap for Humans?"”, Critical care medicine, vol. 46 (6) , pp. 1038–1040, 2018.
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“Reply to Riche et al.: Sevoflurane in Acute Respiratory Distress Syndrome: Are Lung Protection and Anesthesia Depth Influenced by Pulmonary Morphology?”, American journal of respiratory and critical care medicine, vol. 197 (6) , pp. 832–834, 2018.
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“Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.”, Scientific reports, vol. 8 (1) , pp. 2603, 2018.
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“High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.”, Critical care (London, England), vol. 22 (1) , pp. 3, 2018.
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“Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.”, Disease markers, vol. 2018 , pp. 7849675, 2018.
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2017
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“RAGE inhibition reduces acute lung injury in mice.”, Scientific reports, vol. 7 (1) , pp. 7208, 2017.
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“Recruitment maneuvers in acute respiratory distress syndrome.”, Annals of translational medicine, vol. 5 (14) , pp. 290, 2017.
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“Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol.”, BMJ open, vol. 7 (5) , pp. e015280, 2017.
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“Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.”, American journal of respiratory and critical care medicine, vol. 195 (6) , pp. 792–800, 2017.
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“Rationale, study design and analysis plan of the lung imaging morphology for ventilator settings in acute respiratory distress syndrome study (LIVE study): Study protocol for a randomised controlled trial.”, Anaesthesia, critical care & pain medicine, 2017.
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2016
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“Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.”, Chest, vol. 150 (5) , pp. 998–1007, 2016.
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“Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays.”, Clinical chemistry and laboratory medicine, vol. 54 (5) , pp. 833–42, 2016.
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“Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.”, Anaesthesia, critical care & pain medicine, vol. 35 (2) , pp. 81–6, 2016.
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“A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.”, Disease markers, vol. 2016 , pp. 3501373, 2016.
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2015
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“Association between intraoperative ventilator settings and plasma levels of soluble receptor for advanced glycation end-products in patients without pre-existing lung injury.”, Respirology (Carlton, Vic.), vol. 20 (7) , pp. 1131–8, 2015.
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“Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.”, American journal of respiratory and critical care medicine, vol. 192 (2) , pp. 191–9, 2015.
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“Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.”, Intensive care medicine, vol. 41 (5) , pp. 846–55, 2015.
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“Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.”, PLoS ONE, vol. 10 (8) , pp. e0135857, 2015.
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2013
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“Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.”, PLoS ONE, vol. 8 (5) , pp. e64083, 2013.
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